Voltammetric detection of damage to DNA caused by carcinogenic aminofluorenes using novel electrochemical DNA biosensors
نویسندگان
چکیده
The emissions of gasoline and diesel engines contribute significantly to ever increasing pollution of living environment. A specific part of exhaust gases is composed of carcinogenic derivatives of polycyclic aromatic hydrocarbons. Amino derivatives of parent hydrocarbon fluorene, namely 2-aminofluorene (2-AF) and 2,7-diaminofluorene (2,7-DAF), are well-known hazardous air and water pollutants and their occurrence in living systems is also connected with a metabolic transformation of nitro derivatives of fluorene in mammalian cells. 2-AF is one of the most extensively studied examples of the aromatic amine class of carcinogens and it has been extensively used as a model for studying mechanisms of carcinogenesis.
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